Peer-reviewed veterinary case report
Platelet function testing in dogs having liver biopsy
By Shropshire, S B et al.·Published in The Journal of small animal practice·2022·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Multiplate platelet aggregometry in dogs undergoing laparoscopic liver biopsy for diagnosis of chronic hepatopathy.
- Species:
- dog
Plain-English summary
A group of 27 dogs undergoing a liver biopsy for chronic liver disease were tested for platelet function before the procedure. The results showed that 63% of these dogs had decreased platelet function, which could affect their ability to stop bleeding. Many also had other blood abnormalities, such as low platelet counts and increased levels of certain proteins related to clotting. This suggests that dogs with chronic liver disease may be at a higher risk for bleeding during surgery. Further research is needed to understand the implications of these findings better.
People also search for: dog liver biopsy risks · chronic liver disease in dogs · dog bleeding problems after surgery
Abstract
OBJECTIVES: To assess platelet function via the Multiplate analyser in dogs undergoing laparoscopic liver biopsy for diagnosis of chronic hepatopathy. MATERIALS AND METHODS: Twenty-seven client-owned dogs were prospectively enrolled. Before laparoscopic liver biopsy, whole blood impedance platelet aggregometry via the Multiplate analyser was performed. Buccal mucosal bleeding time was performed in 23 of 27 dogs. Tissue factor-activated thromboelastography was also performed, in addition to plasma-based coagulation testing. Descriptive statistics were calculated and the prevalence of platelet function abnormalities and results of other biochemical and coagulation testing were reported. RESULTS: Seventeen (63%) of 27 dogs had evidence of decreased platelet function as assessed by aggregometry, with all 17 dogs having decreased responsiveness to adenosine diphosphate, and 11 of 17 dogs demonstrating decreased responsiveness to arachidonic acid. Based on maximum amplitude, most dogs were classified as normocoagulable on thromboelastography (15/25; 60%). Other frequent coagulation abnormalities included increased D-dimers (20/27;74%), thrombocytopenia (11/27; 41%), hypofibrinogenemia (4/27; 15%), and decreased antithrombin (4/27; 15%). CLINICAL SIGNIFICANCE: Decreased platelet function as assessed by whole blood impedance aggregometry was common in dogs with chronic liver disease. Further study is necessary to determine whether this finding is repeatable or indicative of increased bleeding risk.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34961927/