Peer-reviewed veterinary case report
Dog with multiple small skin nodules diagnosed as ganglioneuromas
By Hermeyer, K et al.·Published in Veterinary dermatology·2007·Department of Pathology, Germany·View original on PubMed →
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Original publication title: Multiple cutaneous ganglioneuromas in a dog.
- Species:
- dog
Plain-English summary
A 3-year-old male Labrador retriever was brought to the vet because he had several small lumps on his skin, mainly on his chest, side, and scrotum. The dog was otherwise healthy, and tests showed no internal tumors. After removing a couple of the lumps for examination, the vet found they were benign growths called ganglioneuromas, which are similar to a type of tumor seen in humans. Fortunately, these lumps are not harmful, and the dog is expected to do well after their removal.
People also search for: dog skin lumps treatment · Labrador retriever skin tumors · benign skin growths in dogs
Abstract
A 3-year-old male Labrador retriever dog was presented with multifocal small cutaneous nodules, distributed mainly over the thoracic wall, the flank and the scrotum. The dog was otherwise in good health and had no significant past medical history. Radio- and sonographic examination revealed no evidence of internal tumours, including endocrine tumours. Histological examination of two excised samples revealed round, non-ulcerated nodules in the superficial corium, characterized by two different neoplastic cell components and mild inflammation. The first tumour cell population showed histomorphological characteristics of mature ganglion cells; the second featured small, spindle-shaped tumour cells with scant cytoplasm. Both neoplastic cell components expressed vimentin, neurofilament protein, pan-neuronal neurofilament, amyloid-precursor protein and chromogranin A. In addition, the spindle-shaped tumour cells were positive for 2', 3'-cyclicnucleotide 3'-phosphodiesterase. The findings had many histological and immunohistochemical features in common with primary cutaneous ganglioneuromas in humans, enabling the canine tumours to be also classified as multiple cutaneous ganglioneuromas.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17845625/