Peer-reviewed veterinary case report
Dog with multiple ulcerated skin nodules and unusual cell nuclei
By Lee, Jongbok et al.·Published in Veterinary medicine and science·2020·College of Veterinary Medicine, South Korea·View original on PubMed →
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Original publication title: Multiple cutaneous plasmacytosis with multilobated (clover-leaf shaped) nuclei cells in a dog.
- Species:
- dog
Plain-English summary
A 12-year-old female Shih Tzu was brought in with multiple non-itchy, ulcerated nodules on her eyelids, lips, abdomen, groin, thighs, and perianal area that had been present for two months. After various tests, the vet found that the nodules were caused by abnormal round cells, but the exact source of these cells was unclear. The dog was treated with chemotherapy, which helped improve her skin condition. Unfortunately, despite the treatment's success, her overall health declined, and she was euthanized.
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Abstract
A 12-year-old female Shih-tzu dog was presented with a 2-month history of cutaneous non-pruritic multiple ulcerated or crusted nodules of less than 1.5 cm in diameter on eyelids, lips, abdomen, groin, thighs and perianal region. Several diagnostic tests were performed, including fine needle aspiration and skin biopsy of the cutaneous nodules. Cytologic interpretation was round cell neoplasm with multilobated (clover-leaf shaped) nuclei. Histopathology revealed round neoplastic cells with prominent anisocytosis and anisokaryosis, and numerous mitotic figures; however, the origin of the cells was not identified. Immunohistochemical evaluation indicated that these cells were positive for CD79a and MUM-1, but negative for CD3, CD20 and Pax 5. The patient was treated with chemotherapy, and the skin condition improved. Despite good response to chemotherapy, the patient was euthanized due to poor general health.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32056392/