Peer-reviewed veterinary case report
Genetic links to dilated heart disease in Irish Wolfhounds
By Simpson, Siobhan et al.·Published in BioMed research international·2016·Faculty of Medicine and Health Sciences, United Kingdom·View original on PubMed →
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Original publication title: Multiple Genetic Associations with Irish Wolfhound Dilated Cardiomyopathy.
- Species:
- dog
Plain-English summary
A study found that Irish Wolfhounds are at risk for dilated cardiomyopathy (DCM), a serious heart disease. Researchers looked at different genetic markers to see how they might contribute to the development of DCM in this breed. While some genetic markers were linked to the disease, none of them alone significantly increased the risk. However, when three specific genetic markers were combined, they did show a higher risk for developing DCM compared to the general population. This suggests that multiple genetic factors work together to influence heart disease in Irish Wolfhounds.
People also search for: Irish Wolfhound heart disease · dilated cardiomyopathy in dogs · genetic testing for dog heart problems
Abstract
Cardiac disease is a leading cause of morbidity and mortality in dogs and humans, with dilated cardiomyopathy being a large contributor to this. The Irish Wolfhound (IWH) is one of the most commonly affected breeds and one of the few breeds with genetic loci associated with the disease. Mutations in more than 50 genes are associated with human dilated cardiomyopathy (DCM), yet very few are also associated with canine DCM. Furthermore, none of the identified canine loci explain many cases of the disease and previous work has indicated that genotypes at multiple loci may act together to influence disease development. In this study, loci previously associated with DCM in IWH were tested for associations in a new cohort both individually and in combination. We have identified loci significantly associated with the disease individually, but no genotypes individually or in pairs conferred a significantly greater risk of developing DCM than the population risk. However combining three loci together did result in the identification of a genotype which conferred a greater risk of disease than the overall population risk. This study suggests multiple rather than individual genetic factors, cooperating to influence DCM risk in IWH.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28070514/