Peer-reviewed veterinary case report
Multiple stem cell injections to treat dog osteoarthritis
By Li, Xianqiang et al.·Published in Cells·2025·College of Veterinary Medicine/Bio-Medical Center, China·View original on PubMed →
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Original publication title: Multiple Intra-Articular Injections of Adipose-Derived Mesenchymal Stem Cells for Canine Osteoarthritis Treatment.
- Species:
- dog
Plain-English summary
A group of dogs with osteoarthritis (OA), a painful joint condition, received multiple injections of stem cells derived from their own fat to see if it would help reduce inflammation and improve cartilage repair. The treatment showed promising results, with noticeable improvements in cartilage health and reduced inflammation compared to dogs that did not receive the injections. This suggests that using fat-derived stem cells could be a beneficial option for managing OA symptoms in dogs, potentially leading to better mobility and comfort.
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Abstract
Osteoarthritis (OA) is one of the most common degenerative diseases in dogs and humans, which can lead to articular cartilage deterioration, chronic pain, and decreased quality of life. The anti-inflammatory, anti-fibrotic, analgesic, and cartilage regeneration properties of mesenchymal stem cell (MSC) therapy provide a new direction for the treatment development of OA in the future. Currently, MSC therapy lacks confirmed ideal sources, dosages, formulations, and specific characteristics. In this study, we evaluated the efficacy of multiple canine adipose-derived mesenchymal stem cell (ADSC) injections on anti-inflammation and joint cartilage damage in a canine OA model. Considering animal ethics, we simulated the effects of inflammation and cartilage repair during treatment through a mouse OA model. In the mouse OA model, through the detection of cartilage repair and inflammation-related key factors via histology and molecular biology, it was found that MSC therapy has a certain repair effect on cartilage, but the anti-inflammatory effect is time-dependent. In the canine OA model, we verified the feasibility of multiple injections of ADSCs. Compared with the control group, the cartilage repair effect of the treatment group was obvious, and the inflammatory factors decreased, showing an obvious therapeutic effect. This study demonstrates that multiple intra-articular injections of canine ADSCs could be effective in treating OA symptoms.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40072052/