Peer-reviewed veterinary case report
Horse developing multiple tongue masses - what could it be?
By Vashisht, K et al.·Published in Veterinary pathology·2007·University of Illinois at Urbana, United States·View original on PubMed →
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Original publication title: Multiple masses in a horse's tongue resulting from an atypical perineurial cell proliferative disorder.
- Species:
- horse
Plain-English summary
A 5-year-old National Show horse mare had a soft lump on the side of her tongue, which over the next two years turned into several larger masses that spread from the side of her tongue to the tip. These masses were made up of unusual cells that were found around the nerves in her tongue. While the exact nature of these cells is still uncertain, they were identified using specific tests that showed they were not typical nerve-related tumors. The condition is still being studied to determine if it is a type of tumor or something else.
Abstract
A 5-year-old National Show horse mare presented with a soft mass on the left dorsolateral aspect of the tongue. Over the next 2 years, the mare developed numerous, similar, coalescing masses that extended along the left dorsolateral aspect to the tip of the tongue. Microscopically, the bases for these masses were slender, fusiform, mesenchymal cells that formed compact whorls around myelinated and unmyelinated nerves. These cells were labeled by antibodies directed against vimentin but not by S-100. Ultrastructurally, multiple, concentrically arranged, long, slender cell processes, with discontinuous external laminae and many pinocytotic vesicles, helped to accurately phenotype the proliferative element. Whether this unusual perineurial cell proliferative disorder is neoplastic or not remained a matter of conjecture.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17491087/