Peer-reviewed veterinary case report
Black skin bumps from papillomavirus in immunosuppressed Boxer dog
By Le Net, J L et al.·Published in Veterinary pathology·1997·Pfizer, France·View original on PubMed →
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Original publication title: Multiple pigmented cutaneous papules associated with a novel canine papillomavirus in an immunosuppressed dog.
- Species:
- dog
Plain-English summary
A 6-year-old female Boxer was brought in with multiple black, rounded bumps on her belly after being on long-term steroid medication for skin allergies. The bumps were diagnosed as a viral infection caused by a new type of canine papillomavirus. After stopping the steroids, the bumps began to disappear on their own within three weeks. This case highlights how some skin issues can resolve once the underlying treatment is adjusted.
People also search for: dog skin bumps treatment · Boxer papillomavirus infection · atopic dermatitis dog steroids
Abstract
Cutaneous papillomavirus infection was diagnosed in a 6-year-old female Boxer dog that was under long-term corticosteroid therapy for atopic dermatitis. Multiple black, rounded papules were present on the ventral skin. Spontaneous regression occurred within 3 weeks after cessation of corticosteroids. Histologically, the lesions consisted of well-demarcated cup-shaped foci of epidermal endophytic hyperplasia with marked parakeratosis. In the upper stratum spinosum and in the stratum granulosum, solitary or small collections of enlarged keratinocytes were observed with basophilic intranuclear inclusion bodies and a single eosinophilic fibrillar cytoplasmic inclusion. Ultrastructurally, viruslike particles (40-45 nm in diameter) were observed within the nucleus, free or aggregated in crystalline arrays. Undulating fibrillar material, thought to be a modified keratin protein, was observed in the cytoplasmic inclusion. Immunohistochemistry, restriction enzyme analysis, and molecular hybridization experiments indicated that these distinctive clinical, histologic, and cytologic features were associated with a novel canine papillomavirus.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/9150540/