Peer-reviewed veterinary case report
Dog with multiple spinal nerve tumors like human schwannomatosis
By Jun Lai Tse et al.·Published in Journal of Veterinary Diagnostic Investigation·2025·View original on Semantic Scholar →
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Original publication title: Multiple spinal nerve sheath tumors in a dog resembling schwannomatosis in humans
- Species:
- dog
Plain-English summary
A 7-year-old male neutered crossbreed dog was brought to the vet after experiencing worsening weakness and inability to walk for nine months. An MRI showed multiple tumors on his spinal nerves, which were causing his symptoms. Despite treatment with steroids, his condition continued to decline, and a follow-up MRI showed the tumors had grown. Unfortunately, due to the severity of his symptoms, the dog was euthanized. The tumors were confirmed to be schwannomas, a type of nerve sheath tumor.
People also search for: dog weakness and inability to walk · dog spinal tumors treatment · schwannoma in dogs
Abstract
A 7-y-old male neutered crossbreed dog was presented to a veterinary referral hospital with a 9-mo history of progressive non-ambulatory tetraparesis. A magnetic resonance imaging (MRI) study revealed multiple T2-weighted hyperintense intradural nodular lesions within the cervical spinal cord and nerves that were contrast-enhancing in T1-weighted post-contrast images. Neurologic signs progressed despite steroid treatment and a second MRI revealed slight enlargement of the previously seen lesions. The dog was euthanized due to severe neurologic signs. Histopathology and immunohistochemistry (laminin, S100, SOX10) confirmed multiple spindle-cell tumors from cervical spinal nerves, consistent with schwannomas. Neoplastic cells occasionally contained a large, clear vacuole (lipoblast-like change). The clinical and pathologic presentation resembles schwannomatosis, a hereditary condition in humans.
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Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/40331640