Peer-reviewed veterinary case report
Increased brain inflammation chemicals CXCL1 and MCP-1 in dogs
By Barber, Renee M et al.·Published in Frontiers in veterinary science·2023·Department of Small Animal Medicine and Surgery, United States·View original on PubMed →
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Original publication title: Multiplex analysis of cytokines in the cerebrospinal fluid of dogs after ischemic stroke reveals elevations in chemokines CXCL1 and MCP-1.
- Species:
- dog
Plain-English summary
A group of 15 dogs diagnosed with ischemic stroke showed higher levels of certain inflammatory proteins in their cerebrospinal fluid compared to healthy dogs. Specifically, two proteins, CXCL1 and MCP-1, were found in much greater amounts in the dogs that had a stroke. This suggests that these proteins could be important in understanding how strokes affect dogs and might help guide future treatments. While the study didn't focus on specific treatments for the dogs, it highlights potential areas for further research to improve outcomes for dogs suffering from strokes.
People also search for: dog stroke symptoms · elevated cytokines in dogs · treatment for dog stroke · dog cerebrospinal fluid analysis · what to do if my dog has a stroke
Abstract
INTRODUCTION: Neuroinflammation that occurs in the brain after stroke has been shown to be important to disease pathogenesis and outcomes. The aim of this study was to evaluate a large number of pro- and anti-inflammatory cytokines in dogs with clinically-confirmed, naturally occurring stroke. MATERIALS AND METHODS: Fifteen dogs with a clinical diagnosis of ischemic stroke and ten healthy control dogs were included in the study. A multiplex immunoassay was utilized to evaluate cerebrospinal fluid for GM-CSF, IFN-γ, IL-2, IL-4, IL-6, IL-7, IL-8, IL-10, IL-15, IL-18, IP-10, CXCL1, MCP-1, and TNF-α. RESULTS: Mean concentrations of CXCL1 (stroke-436 pg/ml, control-267 pg/ml,= 0.01) and MCP-1 (stroke-196 pg/ml, control-66 pg/ml,≤ 0.0001) were significantly elevated in dogs with stroke when compared with control dogs. Location and type of infarct, duration of clinical signs, and use of anti-inflammatory medications were not associated with differences in cytokine concentration. DISCUSSION: CXCL1 and MCP-1 may play a role in naturally occurring canine stroke and represent targets for future research.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37266378/