Peer-reviewed veterinary case report
Murine gammaherpesvirus 68 encodes a second PML-modifying protein.
- Journal:
- Journal of virology
- Year:
- 2014
- Authors:
- Sewatanon, Jaturong & Ling, Paul D
- Affiliation:
- Department of Molecular Virology and Microbiology · United States
- Species:
- rodent
Abstract
The ORF75c tegument protein of murine gammaherpesvirus 68 (MHV68) promotes the degradation of the antiviral promyelocytic leukemia (PML) protein. Surprisingly, MHV68 expressing a degradation-deficient ORF75c replicated in cell culture and in mice similar to the wild-type virus. However, in cells infected with this mutant virus, PML formed novel track-like structures that are induced by ORF61, the viral ribonucleotide reductase large subunit. These findings may explain why ORF75c mutant viruses unable to degrade PML had no demonstrable phenotype after infection.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24371073/