Peer-reviewed veterinary case report
Muscle healing and inflammation in dogs with inflammatory myopathy
By Salvadori, Claudia et al.·Published in Muscle & nerve·2005·Department of Animal Pathology, Italy·View original on PubMed →
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Original publication title: Muscle regeneration, inflammation, and connective tissue expansion in canine inflammatory myopathy.
- Species:
- dog
Plain-English summary
A group of dogs diagnosed with inflammatory myopathy (a muscle disease causing weakness and pain) had muscle biopsies taken to study their condition. The results showed that these dogs had significant muscle regeneration despite the inflammation and damage. Researchers found high levels of certain proteins related to inflammation, indicating that while the muscle was trying to heal, the ongoing inflammation was a concern. The findings suggest that if the inflammation can be controlled, dogs may recover better from this condition.
People also search for: dog muscle disease treatment · inflammatory myopathy in dogs · dog muscle weakness recovery
Abstract
Inflammatory myopathies (IMs) are relatively common in dogs, and canine IMs have many similarities to human IMs. The aim of this work was to analyze aspects of the pathogenesis of canine IM with an ultimate goal of establishing canine IM as a model for human IM. Muscle biopsies from 16 dogs with a histological diagnosis of IM were analyzed to determine degree of muscle regeneration, presence of eosinophils, expression of selected cytokines and chemokines, and extent of fibrosis. Regeneration, as shown by staining for developmental myosin heavy chain, was more extensive than evidenced with hematoxylin-eosin staining in most cases of canine IM. Expression of mRNA encoding transforming growth factor-beta (TGF-beta) and eotaxin 3 was upregulated in all cases evaluated. Eosinophils were abundant in most cases, and the connective tissue was variably expanded, as demonstrated by the distribution of the ubiquitous extracellular matrix proteins collagen VI and fibrillin. The extensive regeneration demonstrates that muscle may survive this adverse environment if inflammation and fibrosis can be stopped or reduced.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15736299/