Peer-reviewed veterinary case report
Mutation in IRO1 tightly linked with URA3 gene reduces virulence of Candida albicans.
- Journal:
- Microbiology and immunology
- Year:
- 2005
- Authors:
- Chibana, Hiroji et al.
- Affiliation:
- Chiba University · Japan
Abstract
Gene deletion in the pathogenic fungus Candida albicans has relied heavily on a URA3 cassette and a recipient delta ura3 strain CAI4. The IRO1 gene adjacent to URA3 was inadvertently deleted during construction of CAI4. We report here that a mutation in IRO1 reduces virulence of C. albicans.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16237272/