Peer-reviewed veterinary case report
Mycobacterium avium subsp. paratuberculosis in Veterinary Medicine.
- Journal:
- Clinical microbiology reviews
- Year:
- 2001
- Authors:
- Harris, N B & Barletta, R G
- Affiliation:
- Department of Veterinary and Biomedical Sciences · United States
Plain-English summary
Mycobacterium avium subsp. paratuberculosis is a bacteria that causes a serious stomach illness called Johne's disease in animals like cows. This disease leads to significant financial losses in the cattle industry, costing around $1.5 billion each year in the United States. Researchers are also looking into whether this bacteria might be linked to Crohn's disease in humans. The article discusses how this bacteria spreads, how it causes disease, and ways to diagnose and control it, including new genetic tools to identify different strains. Overall, the findings suggest that advancements in research could help improve diagnostic and treatment options for this important veterinary issue.
Abstract
Mycobacterium avium subsp. paratuberculosis (basonym M. paratuberculosis) is the etiologic agent of a severe gastroenteritis in ruminants known as Johne's disease. Economic losses to the cattle industry in the United States are staggering, reaching $1.5 billion annually. A potential pathogenic role in humans in the etiology of Crohn's disease is under investigation. In this article, we review the epidemiology, pathogenesis, diagnostics, and disease control measures of this important veterinary pathogen. We emphasize molecular genetic aspects including the description of markers used for strain identification, diagnostics, and phylogenetic analysis. Recent important advances in the development of animal models and genetic systems to study M. paratuberculosis virulence determinants are also discussed. We conclude with proposals for the applications of these models and recombinant technology to the development of diagnostic, control, and therapeutic measures.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/11432810/