Peer-reviewed veterinary case report
Mycobacterium bovis infection in a horse with granulomatous enterocolitis.
- Journal:
- Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
- Year:
- 2015
- Authors:
- Sarradell, Javier E et al.
- Affiliation:
- Department of General and Systemic Pathology
- Species:
- horse
Plain-English summary
A 2-year-old dappled Percheron horse was losing weight and not getting better despite being treated with antibiotics. After the horse sadly passed away, a thorough examination revealed thickening of the large intestine and swollen lymph nodes in the abdomen, along with small white spots in the liver. Further testing of the affected tissues showed signs of chronic inflammation in the intestines, lymph nodes, and liver, indicating a serious infection. The tests confirmed that the horse was infected with Mycobacterium bovis, a type of bacteria. Unfortunately, the treatment did not work, and the horse did not survive.
Abstract
A 2-year-old dappled Percheron horse had a wasting condition that did not respond to antibiotic treatments and ultimately resulted in death. Thickening of the wall of the large colon and enlargement of the mesenteric lymph nodes were observed at postmortem examination, along with the presence of pinpoint whitish foci in the liver. Microscopic examination of affected tissues revealed diffuse chronic granulomatous enterocolitis, granulomatous mesenteric lymphadenitis, and multifocal granulomatous hepatitis. The DNA extracted from paraffin-embedded intestinal and lymph node samples was analyzed using both a polymerase chain reaction (PCR) assay and PCR-restriction endonuclease analysis and demonstrated the presence of Mycobacterium bovis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25677270/