Peer-reviewed veterinary case report
Mycobacterium leprae is naturally resistant to PA-824.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2006
- Authors:
- Manjunatha, Ujjini H et al.
- Affiliation:
- National Institute of Allergy and Infectious Diseases · United States
Abstract
Leprosy responds very slowly to the current multidrug therapy, and hence there is a need for novel drugs with potent bactericidal activity. PA-824 is a 4-nitroimidazo-oxazine that is currently undergoing phase I clinical trials for the treatment of tuberculosis. The activity of PA-824 against Mycobacterium leprae was tested and compared with that of rifampin in axenic cultures, macrophages, and two different animal models. Our results conclusively demonstrate that PA-824 has no effect on the viability of M. leprae in all three models, consistent with the lack of the nitroimidazo-oxazine-specific nitroreductase, encoded by Rv3547 in the M. leprae genome, which is essential for activation of this molecule.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17005816/