Peer-reviewed veterinary case report
Myelin damage in two dogs after fast low sodium fix
By O'Brien, D P et al.Ā·Published in Journal of veterinary internal medicineĀ·1994Ā·Department of Veterinary MedicineĀ·View original on PubMed ā
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Original publication title: Myelinolysis after correction of hyponatremia in two dogs.
- Species:
- dog
Plain-English summary
A 5-year-old Labrador and a 3-year-old Beagle both showed signs of neurological problems after their low sodium levels were corrected too quickly. The Labrador unfortunately did not survive, and a post-mortem examination revealed damage to the brain's thalamus. In contrast, the Beagle gradually improved and did not have any lasting neurological issues. This situation highlights the importance of carefully managing sodium levels in dogs to avoid serious complications.
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Abstract
Two dogs developed delayed neurological deterioration after rapid correction of severe hyponatremia. Sequential magnetic resonance imaging showed the development of lesions in the thalamus. One dog was necropsied, and the lesions were characterized by myelinolysis with sparing of axons and neurons. The second dog gradually recovered with no detectable neurological deficits. The syndrome seems analogous to central pontine myelinolysis in human beings. Guidelines for correction of hyponatremia to prevent development of myelinolysis are given.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8176662/