Myeloid-Derived Suppressor Cells Infiltrate the Brain and Suppress Neuroinflammation in a Mouse Model of Focal Traumatic Brain Injury.

Abstract

Myeloid-derived suppressor cells (MDSCs) have strong immunosuppressive characteristics, which allow them to limit inflammation and facilitate wound healing and recovery. Although MDSCs are a newly-determined cell type that is gaining attention in the immunology field, their neuroimmunological characteristics remain unstudied. In this study, we explored the suppressive role of MDSCs in cerebral inflammatory reactions after focal traumatic brain injury (TBI) using in vivo imaging. Through morphological, functional, and phenotypic analyses we determined that CD11b/Gr-1cells infiltrating the contusion area are MDSCs. MDSCs are among the first responders to tissue injury, responding even prior to microglial activation. Positron emission tomography imaging of translocator protein results suggest that infiltrating MDSCs suppress neuronal inflammation and interact with resident immune cells, like microglia, following focal TBI.