Peer-reviewed veterinary case report
Myocardial Induction of Type 3 Deiodinase in Dilated Cardiomyopathy.
- Journal:
- Thyroid : official journal of the American Thyroid Association
- Year:
- 2017
- Authors:
- Wassner, Ari J et al.
- Affiliation:
- Boston Children's Hospital · United States
- Species:
- rodent
Abstract
BACKGROUND: The thyroid hormone-inactivating enzyme type 3 deiodinase (D3) is induced during hypertrophic and ischemic cardiomyopathy, leading to a state of local cardiac hypothyroidism. Whether D3 induction occurs in dilated cardiomyopathy is unknown. METHODS: This study characterized changes in cardiac D3 and thyroid hormone signaling in a transgenic model of progressive dilated cardiomyopathy (TG9 mice). RESULTS: Cardiac D3 was dramatically induced 15-fold during the progression of dilated cardiomyopathy in TG9 mice. This D3 induction localized to cardiomyocytes and was associated with a decrease in myocardial thyroid hormone signaling. CONCLUSIONS: Cardiac D3 is induced in a mouse model of dilated cardiomyopathy, indicating that D3 induction may be a general response to diverse forms of cardiomyopathy.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28314380/