Peer-reviewed veterinary case report
Cat with vomiting and liver nodules from eosinophilic fibroplasia
By Giannino, Darian L et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2025·Department of Population Medicine and Diagnostic Sciences, United States·View original on PubMed →
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Original publication title: Myofibroblast differentiation in a cat with eosinophilic sclerosing fibroplasia involving mesenteric lymph nodes and liver.
- Species:
- cat
Plain-English summary
An 11-year-old spayed female domestic shorthair cat was brought to the vet after experiencing vomiting and not eating for 1-2 months. The vet found swollen lymph nodes in her abdomen and multiple nodules in her liver. Tests showed that the liver and lymph nodes had significant inflammation and scarring, which is typical of a rare condition called eosinophilic sclerosing fibroplasia (FESF). While there were no obvious issues in her gastrointestinal tract, the findings highlighted the role of certain immune cells in the cat's condition. Treatment details were not specified, but understanding this unique case can help in managing similar cases in the future.
People also search for: cat vomiting and not eating · cat liver disease symptoms · eosinophilic sclerosing fibroplasia in cats
Abstract
Feline eosinophilic sclerosing fibroplasia (FESF) is a unique fibroproliferative disease of cats marked by eosinophilic inflammation and extensive tissue fibroplasia that affects the gastrointestinal tract predominantly. Biopsy specimens were examined from an 11-y-old, spayed female, domestic shorthair cat with a 1-2-mo history of vomiting and anorexia, abdominal lymphadenopathy, and multiple hepatic nodules. Microscopically, the liver nodules and enlarged mesenteric lymph node had profound eosinophilic inflammation and sclerosis characteristic of FESF; the stomach, duodenum, jejunum, and ileum were unremarkable. Immunohistochemistry (IHC) was performed to further characterize the cell populations. Increased intralesional mesenchymal cells, interpreted as reactive fibroblasts, were positive with antibodies against smooth muscle actin (SMA), indicating a myofibroblast phenotype. Abundant intralesional macrophages were ionized calcium-binding adapter molecule 1 (IBA1) immunolabeled. Dual IHC of SMA and IBA1 revealed several double-positive mesenchymal cells, suggesting macrophage-to-myofibroblast transition (MMT). Our findings underscore the important role of macrophages not only in chronic inflammation, but also in tissue repair and fibrosis. Our case was a unique presentation of FESF with primary liver and mesenteric lymph node involvement, and without overt gastrointestinal lesions. Additionally, to our knowledge, myofibroblast phenoconversion and MMT have not been reported previously in cats, giving new insights to the pathogenesis of this poorly understood disease entity.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40356060/