Peer-reviewed veterinary case report
Myofibroblastic fibrosarcoma with multifocal osseous metaplasia at the site of equine influenza vaccination.
- Journal:
- Australian veterinary journal
- Year:
- 2010
- Authors:
- Kannegieter, N J et al.
- Affiliation:
- Roseville Equine Clinic · Australia
- Species:
- horse
Plain-English summary
A 12-year-old Quarterhorse x Arabian gelding developed a fibrosarcoma, which is a type of cancer, at the site of his equine influenza vaccination. Shortly after receiving his second shot, the owner noticed swelling that grew larger over the next six months. A biopsy showed that the mass was about 20 cm wide and raised above the skin, but there were no signs that the cancer had spread to the lungs or nearby lymph nodes. The mass was surgically removed, and the wound healed well. This case is notable because it appears to be the first reported instance of a vaccine-related fibrosarcoma in horses, and the treatment was successful in removing the tumor.
Abstract
We describe a fibrosarcoma in a 12-year-old Quarterhorse x Arabian gelding as a sequela to equine influenza vaccination. Shortly after the second vaccination, swelling at the site was noticed by the owner and it continued to increase in size over the following 6 months. Biopsy of the mass indicated a fibrosarcoma had developed at the vaccination site. It was approximately 20 cm in diameter and elevated well above the level of the skin. There was no clinical evidence of metastases to the lungs or local lymph nodes. Surgical resection of the mass was performed and the wound healed by first and second intention. Histopathological examination and immunohistochemical staining confirmed a myofibroblastic fibrosarcoma with multifocal osseous metaplasia. To the authors' knowledge, this is the first equine case of a vaccine-associated fibrosarcoma.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20402700/