Peer-reviewed veterinary case report
Myoglobin levels predict survival in dogs with gastric
By Adamik, Katja N et al.Ā·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Ā·2009Ā·Clinic of Small Animals, GermanyĀ·View original on PubMed ā
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Original publication title: Myoglobin as a prognostic indicator for outcome in dogs with gastric dilatation-volvulus.
- Species:
- dog
Plain-English summary
A group of 72 dogs diagnosed with gastric dilatation-volvulus (GDV), a serious stomach condition, had their myoglobin levels tested to see if it could predict their chances of survival. The results showed that dogs with lower myoglobin levels at diagnosis were more likely to survive, while those with higher levels had a much lower survival rate. Specifically, nearly 90% of dogs with myoglobin levels below 168 ng/mL survived, compared to 50% of those above that level. This suggests that measuring myoglobin can help veterinarians assess the prognosis for dogs with GDV.
People also search for: dog GDV prognosis Ā· myoglobin levels in dogs Ā· gastric dilatation-volvulus survival rate
Abstract
OBJECTIVE: To determine whether myoglobin (Mb) is a useful prognostic indicator for outcome and to investigate any relationship between Mb and mortality in dogs with gastric dilatation-volvulus (GDV). DESIGN: Prospective study. SETTING: Veterinary teaching hospital. ANIMALS: Seventy-two dogs with GDV. INTERVENTIONS: Blood sampling. MEASUREMENTS AND MAIN RESULTS: Mb levels were measured at the time of diagnosis (Mbt0), 24 hours (Mbt1), and 48 hours (Mbt2) after signs of GDV were recognized. Fifty-seven dogs survived (group I) and 15 dogs did not survive (group II). Mbt0 differed significantly between groups (P=0.04). Mbt0 in group I ranged from <30 to >700 ng/mL (n=57, median 74 ng/mL), and in group II from 34 to >700 ng/mL (n=15, median 238 ng/mL). Analysis of a receiver operating characteristic curve of Mbt0 suggested that the best single cutpoint would be 168 ng/mL (sensitivity 60.0%, specificity 84.2%). Fifty percent of dogs with Mbt0>168 ng/mL were euthanized, while 88.9% with Mbt0<168 ng/mL survived. Mbt1 and Mbt2 differed significantly between groups I and II. Mbt1 in group I ranged from 32 to >700 ng/mL (n=55, median 123 ng/mL), and Mbt1 in group II ranged from 131 to 643 ng/mL (n=7, median 343 ng/mL) (P=0.006). Mbt2 in group I ranged from 30 to 597 ng/mL (n=54, median 101 ng/mL), and in group II from 141 to >700 ng/mL (n=8, median 203 ng/mL) (P=0.02). CONCLUSIONS: In this study, Mbt0 is a moderately sensitive and specific prognostic indicator. Almost 90% of the dogs below the cutpoint survived to discharge, whereas 50% with Mbt0 above the cutpoint did not survive.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19691509/