Peer-reviewed veterinary case report
Muscle damage and blood marker changes in dogs with liver disease
By Neumann, Stephan et al.·Published in Research in veterinary science·2008·Institute of Veterinary Medicine, Germany·View original on PubMed →
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Original publication title: Myopathy and alterations in serum 3-methylhistidine in dogs with liver disease.
- Species:
- dog
Plain-English summary
A group of 28 dogs with liver disease showed signs of muscle problems, which were confirmed through tests like muscle biopsies and blood tests. The study found that a substance called 3-methylhistidine, which indicates muscle damage, was significantly higher in dogs with liver tumors and also elevated in those with severe hepatitis. This suggests that liver disease can affect muscle health in dogs. Understanding these changes can help veterinarians better assess and treat dogs suffering from liver issues.
People also search for: dog liver disease symptoms · muscle problems in dogs · elevated 3-methylhistidine in dogs · liver tumors in dogs · dog muscle biopsy results
Abstract
Liver disease can influence the metabolism of various other organs. Regarding the influence of liver diseases on muscles, only a few studies done on people exist. The goal of our study was to investigate the influence of liver diseases on muscles in dogs. Twenty-eight dogs with different liver diseases were investigated in this study. The diagnosis of muscle alteration was based on electromyography (EMG), creatine kinase serum activity, 3-methylhistidine serum concentration and a muscle biopsy in some cases. Our results suggest that liver diseases in dogs can be accompanied with muscle alteration. 3-Methylhistidine serum concentration as a new parameter for muscle destruction in dogs was significantly increased compared to clinical healthy dogs and was comparable to those concentrations in dogs with histologically confirmed myopathy of different types. The differentiation of the liver diseases into severe hepatitis, moderate hepatitis and liver tumours showed a significant elevation of 3-methylhistidine serum concentration in cases of liver tumours (P=0.03) and a tendency in cases of severe hepatitis (P=0.07). Based on our study we can conclude that liver diseases have an influence on muscles in dogs and 3-methylhistidine could be a useful parameter for muscle destruction.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17643456/