Peer-reviewed veterinary case report
Myxoma virus induces apoptosis in cultured feline carcinoma cells.
- Journal:
- Research in veterinary science
- Year:
- 2012
- Authors:
- MacNeill, A L et al.
- Affiliation:
- Department of Pathobiology · United States
Abstract
There is growing interest in utilizing replicating oncolytic viruses as cancer therapeutics agents. The effectiveness of myxoma virus-induced oncolysis was evaluated in two feline cancer cell cultures. Although myxoma virus is a rabbit-specific pathogen, protein expression driven by myxoma virus and production of infectious viral particles were detected. Cell death occurred in primary feline cancer cells within 48 h of inoculation with myxoma virus. Future studies to determine if other feline neoplasms are susceptible to myxoma virus infection are warranted.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22100245/