Peer-reviewed veterinary case report
Higher angiopoietin-2 levels linked to heart valve disease and lung
By Yu, Hogeun et al.·Published in American journal of veterinary research·2024·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Myxomatous mitral valve disease and associated pulmonary hypertension might increase serum angiopoietin-2 in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with myxomatous mitral valve disease (MMVD), a common heart condition, showed higher levels of a protein called angiopoietin-2 when they also had pulmonary hypertension (PH). This means that as the heart disease worsens and if the dog develops breathing problems due to PH, the angiopoietin-2 levels in their blood increase. The study involved 74 dogs, and the findings suggest that monitoring angiopoietin-2 could help veterinarians assess the severity of heart disease in dogs. Treatment options for MMVD and PH typically include medications to manage heart function and fluid buildup.
People also search for: dog heart disease symptoms · myxomatous mitral valve disease treatment · pulmonary hypertension in dogs
Abstract
OBJECTIVE: To evaluate the relationships between the severity of myxomatous mitral valve disease (MMVD) and pulmonary hypertension (PH) and serum angiopoietin (Ang)-1 and Ang-2 concentrations in dogs with MMVD. ANIMALS: 74 dogs (control, n = 12; MMVD, n = 62) were included. METHODS: Serum Ang-1 and Ang-2 concentrations were estimated using the canine-specific ELISA kit. The concentrations were compared between dogs with MMVD and healthy dogs, and they were analyzed according to the severity of MMVD and PH. RESULTS: The median serum Ang-1 concentration did not differ among the study groups. The median serum Ang-2 concentration was higher in dogs with stage B2 MMVD (P = .041) and acute congestive heart failure (P = .002) than in control dogs. In addition, the median serum Ang-2 concentration was higher in MMVD dogs with PH than in those without PH (P = .031). Serum Ang-2 concentration was correlated with vertebral heart score (rs = 0.36, P = .004) and vertebral left atrial score (r = 0.50, P < .001) in dogs with MMVD, and correlated with vertebral heart score (r = 0.63, P = .01), maximum E wave amplitude of the diastolic transmitral flow (rs = 0.61, P = .018), ejection fraction (rs = -0.77, P < .001) and fractional shortening (rs = -0.56, P = .032) in dogs with acute congestive heart failure. CLINICAL RELEVANCE: Circulating Ang-2 levels increase in dogs with the severity of MMVD and the presence of PH.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38531156/