Peer-reviewed veterinary case report
N-acetylcysteine treatment protects against VEGF-receptor blockade-related emphysema.
- Journal:
- COPD
- Year:
- 2004
- Authors:
- Demura, Yoshiki et al.
- Affiliation:
- University of Colorado Health Sciences Center · United States
- Species:
- rodent
Abstract
Administration of the VEGF receptor blocker SU5416 to rats causes alveolar septal cell apoptosis and emphysema; both can be prevented by a superoxide dismutase mimetic. Here we show that SU5416 induces the expression of heme oxygenase-1 in the lung tissue and that administration of antioxidant N-acetyl-l-cysteine protects alveolar septal cells against apoptosis, as demonstrated by caspase-3 lung immunohistochemistry, and against emphysema.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16997736/