Peer-reviewed veterinary case report
N-methyl-D-aspartate (NMDA)-mediated excitotoxic damage: a mouse model of acute retinal ganglion cell damage.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2013
- Authors:
- Seitz, Roswitha & Tamm, Ernst R
- Affiliation:
- Institute for Human Anatomy and Embryology · Germany
Abstract
The animal model of N-methyl-D-aspartate (NMDA)-induced excitotoxic damage of retinal ganglion cells (RGC) is widely used to study the molecular mechanisms of RGC apoptosis and/or its prevention by neuroprotective agents. This chapter provides protocols for applying NMDA-induced excitotoxic damage to RGC of mouse eyes and for subsequent measuring of the extent of the resulting damage.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23150363/