Peer-reviewed veterinary case report
Naamidine A reveals a promising zinc-binding strategy for topical antifungal therapy.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2024
- Authors:
- Puumala, Emily et al.
- Affiliation:
- Department of Molecular Genetics · Canada
Abstract
Fungal disease affects over a billion people worldwide. Naamidine A inhibits the growth of diverse fungal pathogens through an unknown mechanism. Here, we show that the supplementation of medium with excess zinc abolishes the antifungal activity of naamidine A. Furthermore, we highlight that naamidine A hasactivity against terbinafine-resistant. andefficacy in a mouse model of dermatomycosis caused byhighlighting its therapeutic potential as a topical treatment.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/39324798/