Peer-reviewed veterinary case report
NAG-targeting fluorescence based probe for precision diagnosis of kidney injury.
- Journal:
- Chemical communications (Cambridge, England)
- Year:
- 2019
- Authors:
- Yan, Fei et al.
- Affiliation:
- College of Pharmacy · China
- Species:
- rodent
Abstract
We report an enzyme-activated fluorescence based probe (NHPO) for the selective detection of N-acetyl-β-d-glucosaminidase (NAG) activity in a drug-induced kidney injury mice model and NAG level in crude human urine. We used NHPO to explore the biological functions of NAG and provide a reference for the prognosis and prediction of proximal renal tubular dysfunction associated with various kidney diseases.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/30681673/