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Peer-reviewed veterinary case report

Nanobodies® for veterinary health: multifunctional roles in diagnostics, therapeutics, and vaccines.

Journal:
Trends in microbiology
Year:
2026
Authors:
Ji, Pinpin et al.
Affiliation:
Department of Preventive Veterinary Medicine · China

Plain-English summary

Nanobodies are tiny, stable proteins that come from a special type of antibody found in camels. Because of their small size and flexibility, they are becoming very useful in veterinary medicine. They can help with diagnosing animal diseases, treating illnesses, and even creating new vaccines. This review looks at all the different ways nanobodies can be used to improve the health of animals.

Abstract

Nanobodies® are the recombinant single-domain antigen-binding fragments derived from the variable region of camelid heavy chain-only antibodies. Owing to their small size, exceptional stability, and structural flexibility, they have emerged as valuable biologicals impacting veterinary medicine. This review comprehensively examines their applications across animal disease diagnostics, therapeutics, and vaccine innovation.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/41807231/