Peer-reviewed veterinary case report
Nanocapsules for the co-delivery of selol and doxorubicin to breast adenocarcinoma 4T1 cells in vitro.
- Journal:
- Artificial cells, nanomedicine, and biotechnology
- Year:
- 2018
- Authors:
- Ganassin, Rayane et al.
- Affiliation:
- a Department of Genetics and Morphology · Brazil
Abstract
Nanocapsules (NCS-DOX) with an oily core of selol and a shell of poly(methyl vinyl ether-co-maleic anhydride) covalently conjugated to doxorubicin were developed. These nanocapsules are spherical, with an average hydrodynamic diameter of about 170 nm, and with negative zeta potential. NCS-DOX effectively co-delivered the selol and the doxorubicin into 4T1 cells and changed the intracellular distribution of DOX from the nuclei to the mitochondria. Moreover, a significantly increased cytotoxicity against 4T1 cells was observed, which is suggestive of additive or synergic effect of selol and doxorubicin. In conclusion, PVM/MA nanocapsules are suitable platforms to co-deliver drugs into cancer cells.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29179603/