Peer-reviewed veterinary case report
Nanog protein levels in dog skin mast cell tumors and growth rates
By Joselevitch, Julia A et al.·Published in Veterinary pathology·2018·1 Laborató, Brazil·View original on PubMed →
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Original publication title: Nanog Expression and Proliferation Indices in Canine Cutaneous Mast Cell Tumors.
- Species:
- dog
Plain-English summary
A study looked at skin tumors called mast cell tumors in dogs, which are quite common. Researchers examined samples from 41 dogs to see if a protein called NANOG could help predict how aggressive the tumors were or how long the dogs might survive. They found that while all the tumors showed NANOG, it didn't actually relate to how fast the tumors were growing or the dogs' outcomes. This means NANOG isn't a useful marker for determining the prognosis of these tumors in dogs.
People also search for: dog skin tumor prognosis · mast cell tumor treatment in dogs · what is NANOG in dog tumors
Abstract
Mast cell tumors are one of the most frequent skin tumors in dogs. Treatment decisions often depend on a wide range of clinical information and the main criteria for prognostic formulation are histological grade, mitotic count, Ki67 index, and KIT immunostaining pattern. NANOG is a pluripotency factor expressed by normal and cancer stem cells, which is a prognostic marker and a potential therapeutic target for several human tumors. In the present study, mast cell tumor samples from 41 dogs were evaluated for NANOG and Ki67 by immunohistochemistry. All samples were positive for NANOG but its expression was not correlated with Ki67 index and no significant differences were found with respect to histopathological grades, disease-related mortality, or survival. Our results suggest that, although related to pluripotency, NANOG expression does not correlate with proliferative activity, and is not a reliable prognostic factor for canine cutaneous mast cell tumors.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30025495/