Peer-reviewed veterinary case report
Narrow-band UVB light reduces skin inflammation in beagles
By Onishi-Sakamoto, Saki et al.·Published in Veterinary dermatology·2021·Tokyo University of Agriculture and Technology, Japan·View original on PubMed →
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Original publication title: Narrow-band ultraviolet B therapy attenuates cutaneous T-cell responses in hapten-induced, experimental contact dermatitis in beagles.
- Species:
- dog
Plain-English summary
A group of seven healthy beagles underwent narrow-band ultraviolet B (NB-UVB) therapy to see if it could help with skin inflammation caused by a chemical irritant. After treatment, the dogs showed reduced signs of inflammation and fewer harmful immune responses in their skin without significant damage. This suggests that NB-UVB therapy could be a safe option for treating certain skin problems in dogs. However, more research is needed to confirm its effectiveness in dogs with actual skin issues.
People also search for: dog skin problems treatment · beagle contact dermatitis · NB-UVB therapy for dogs
Abstract
BACKGROUND: In human medicine, narrow-band ultraviolet B (NB-UVB) phototherapy has been used to treat various T-cell-mediated skin diseases. However, the effect of NB-UVB on inflamed canine skin remains uncertain. OBJECTIVES: To investigate the effect of NB-UVB phototherapy on the skin of dogs with hapten-induced contact dermatitis. ANIMALS: Seven healthy beagles without skin problems. METHODS AND MATERIALS: Dogs were irradiated with varying doses of NB-UVB to determine the minimal erythema dose (MED). After determining the MEDs of six dogs (excluding one of the seven whose skin did not show a visible reaction), we investigated the effect of NB-UVB on their inflamed skin by topically applying 2,4-dinitrochlorobenzene (DNCB), which causes type 1 helper T cell (Th1)- and cytotoxic T-cell (Tc)1-induced skin inflammation. We then irradiated the skin with NB-UVB. We analysed the treated skin samples via histopathological and immunohistochemical methods, and TdT-mediated dUTP nick-end labelling (TUNEL) to demonstrate apoptotic cells. We also analysed the cytokine gene transcription via real-time quantitative reverse transcription PCR. RESULTS: The NB-UVB MEDs caused mild inflammatory changes yet no severe epidermal exfoliations in the irradiated skin. In DNCB-treated skin irradiated by the NB-UVB MEDs, TUNEL-positive dermal apoptotic cells were increased significantly compared with those of DNCB-treated, nonirradiated skin. INF-γ and TNF-α transcription levels in DNCB-treated, irradiated skin were significantly lower than those in the DNCB-treated, nonirradiated skin. CONCLUSION AND CLINICAL RELEVANCE: Phototherapy using NB-UVB MEDs attenuated cutaneous Th1 and Tc1 cytokine responses with minimal skin damage in a canine model of hapten-induced contact dermatitis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34796565/