Peer-reviewed veterinary case report
Naturally occurring infections in non-human primates (NHP) and immunotoxicity implications: discussion sessions.
- Journal:
- Journal of immunotoxicology
- Year:
- 2010
- Authors:
- Olivier, Kenneth J et al.
- Affiliation:
- Merrimack Pharmaceuticals · United States
Plain-English summary
This study discusses the health of non-human primates (NHP), which are often used in research to help understand how medications and toxins affect humans. To ensure these animals are healthy and provide useful data, it's crucial to know about the normal germs they carry and to monitor any infections they might have, including viruses, bacteria, parasites, and fungi. The paper summarizes insights from experts in academia, industry, and government about common and new infections in NHP, focusing on how these infections can affect their immune systems and what treatments are available. The overall goal is to improve the care of these animals to enhance the quality of research data.
Abstract
Non-human primates (NHP) are used to best understand and address pharmacology and toxicology obligations for human patients with highest and/or unmet need. In order to ensure the most appropriate care and use of NHP, it is important to understand the normal micro flora and fauna of NHP and ensure their utmost health to generate the most valuable and applicable data. There are many infections, including viral, bacterial, parasitic, and fungal that may perturb physiologic endpoints relevant to human health, and are essential to monitor and/or eradicate for NHP health. This publication captures a discussion involving the experience, knowledge and opinion from academic, industry and government experts regarding emerging and normal infections in NHP as they relate to immunotoxicity, and treatment and consequences of known infections.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20441554/