Peer-reviewed veterinary case report
Naturally-occurring right terminal hairpin mutations in three genotypes of canine parvovirus (CPV-2a, CPV-2b and CPV-2c) have no effect on their growth characteristics.
- Journal:
- Virus research
- Year:
- 2019
- Authors:
- Yu, Yongle et al.
- Affiliation:
- Department of Biochemistry and Molecular Biology · China
- Species:
- dog
Abstract
We have isolated 4 naturally-occurring strains of CPV in mainland China and have identified them as CPV-2, 2a, 2b and 2c genotypes according to their VP2 sequences which also revealed substitutions within their right terminal regions. To determine if these substitutions affected the growth characteristics of the 4 strains, we constructed plasmids based on their genomic sequences minus their right terminal sequences, with the latter replaced by a single right terminal region. Analysis of rescued recombinants showed that the substitutions within their natural right termini had no significant effect on their growth characteristics.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/30557578/