Peer-reviewed veterinary case report
Near-Infrared Fluorescence Endoscopy to Detect Dysplastic Lesions in the Mouse Colon.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2016
- Authors:
- Gounaris, Elias et al.
- Affiliation:
- Department of Surgery · United States
Abstract
Near-infrared fluorescence (NIRF) endoscopy has a great potential for efficient early detection of dysplastic lesions in the colon. For preclinical studies, we developed a small animal NIRF endoscope and successfully used this device to identify dysplastic lesions in a murine model of chronic colitis. In this chapter, we present a step-by-step protocol for using NIRF endoscopy to examine the location, the size, and the borders of the dysplastic lesions developed in murine colitis. Our studies suggest that NIRF endoscopy is a specific and sensitive technique that provides a unique opportunity to analyze early stages of tumorigenesis in animal models of colon cancer and to perform surveillance colonoscopy in patients with colitis-associated colon cancer.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27246029/