Peer-reviewed veterinary case report
Necrotizing brain inflammation in female pugs in Japan
By Kobayashi, Y et al.·Published in Journal of comparative pathology·1994·Department of Comparative Pathology, Japan·View original on PubMed →
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Original publication title: Necrotizing meningoencephalitis in pug dogs in Japan.
- Species:
- dog
Plain-English summary
Three female pug dogs in Japan were diagnosed with necrotizing meningoencephalitis, a serious brain condition that can cause severe neurological symptoms. All three dogs had recently experienced pregnancy or a false pregnancy before showing signs of illness. The symptoms included inflammation in the brain and surrounding areas, leading to brain tissue damage. Unfortunately, the report does not specify the treatment outcomes for these cases, but this condition is known to be very serious and often requires immediate veterinary attention.
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Abstract
This report records necrotizing meningoencephalitis in three pug dogs. It is the first record of the disease in Japan. There were three characteristic histopathological findings, namely (1) a non-suppurative inflammatory cell infiltration of the cerebral hemispheres, including both gray and white matter, (2) meningeal and perivascular infiltrates of mononuclear cells, with a strong tendency to invade the underlying or surrounding brain parenchyma, and (3) selective cerebral cortical necrosis, often occurring without a concurrent inflammatory reaction. The three cases, which were diagnosed as pug dog encephalitis, resembled those previously reported in the United States of America, Switzerland and Italy. All affected animals were females with clinical histories of pregnancy or phantom pregnancy 2 weeks or less before the onset of the clinical signs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8040380/