Peer-reviewed veterinary case report
Nectin4 is an epithelial cell receptor for canine distemper virus and involved in neurovirulence.
- Journal:
- Journal of virology
- Year:
- 2012
- Authors:
- Pratakpiriya, Watanyoo et al.
- Affiliation:
- Department of Veterinary Pathology · Japan
- Species:
- dog
Abstract
Canine distemper virus (CDV) uses signaling lymphocyte activation molecule (SLAM), expressed on immune cells, as a receptor. However, epithelial and neural cells are also affected by CDV in vivo. Wild-type CDV strains showed efficient replication with syncytia in Vero cells expressing dog nectin4, and the infection was blocked by an anti-nectin4 antibody. In dogs with distemper, CDV antigen was preferentially detected in nectin4-positive neurons and epithelial cells, suggesting that nectin4 is an epithelial cell receptor for CDV and also involved in its neurovirulence.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22761370/