Peer-reviewed veterinary case report
Neosporosis as a cause of equine protozoal myeloencephalitis.
- Journal:
- Journal of the American Veterinary Medical Association
- Year:
- 1996
- Authors:
- Marsh, A E et al.
- Affiliation:
- Department of Pathology · United States
- Species:
- horse
Plain-English summary
An 11-year-old Quarter Horse gelding was diagnosed with neosporosis, which is a condition caused by a parasite that can lead to symptoms similar to equine protozoal myeloencephalitis (EPM). The horse showed signs that matched EPM, and tests confirmed the presence of the neosporosis parasite in its tissues. Interestingly, tests also showed that antibodies from this parasite could react with proteins from the parasite typically associated with EPM. This case highlights that neosporosis can look like EPM, suggesting that veterinarians should consider other causes when diagnosing EPM. The outcome of the treatment was not specified in the abstract.
Abstract
Neosporosis was diagnosed in an 11-year-old Quarter Horse gelding with clinical signs and diagnostic test results compatible with equine protozoal myeloencephalitis (EPM). Presumptive postmortem diagnosis of EPM attributable to Sarcocystis neurona infection is generally made on the basis of detecting an antibody titer to S neurona in the CSF or characteristic histologic lesions, even when parasites have not been specifically identified. Neosporosis was confirmed in the horse described here by use of immunohistochemical examination, in vitro culturing, and ultrastructural and molecular characterization of parasites from infected tissues. Antibody testing of serum and CSF samples indicated that Neospora-specific anti-bodies can react with S neurona proteins on western blot analysis. The confirmation that neosporosis in horses can mimic EPM emphasizes the need to broaden the etiologic definition of EPM beyond infections exclusively attributable to S neurona.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/8944807/