Peer-reviewed veterinary case report
Dog with intestinal tumor had extreme thirst and urination that
By Cohen, M & Post, G S·Published in Journal of the American Veterinary Medical Association·1999·Animal Medical Center, United States·View original on PubMed →
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Original publication title: Nephrogenic diabetes insipidus in a dog with intestinal leiomyosarcoma.
- Species:
- dog
Plain-English summary
A 7-year-old dog with intestinal cancer (leiomyosarcoma) was diagnosed with nephrogenic diabetes insipidus, which caused excessive thirst and urination. After the tumor was surgically removed, the dog's symptoms improved significantly, indicating that the diabetes insipidus may have been related to the cancer. However, when the cancer returned, the symptoms also reappeared. This suggests that treating the underlying cancer helped resolve the diabetes insipidus.
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Abstract
Nephrogenic diabetes insipidus was diagnosed in a dog with an intestinal leiomyosarcoma. The diagnosis of nephrogenic diabetes insipidus was made on the basis of results of serum biochemical tests, urinalyses, and a water-deprivation test, along with a lack of response to exogenous administration of vasopressin following the water-deprivation test. The temporal association between resection of the intestinal mass and resolution of clinical signs of diabetes insipidus (i.e., polyuria and polydipsia) and between recurrence of clinical signs and detection of metastatic disease suggests that there may have been a causal relationship, and nephrogenic diabetes insipidus may have developed as a paraneoplastic syndrome in this dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/10613214/