Peer-reviewed veterinary case report
Nephrogenic diabetes insipidus in sibling colts.
- Journal:
- Journal of veterinary internal medicine
- Year:
- 1993
- Authors:
- Schott, H C et al.
- Affiliation:
- Department of Veterinary Clinical Medicine and Surgery · United States
Plain-English summary
Two full sibling Thoroughbred colts were diagnosed with nephrogenic diabetes insipidus, a condition that affects their ability to concentrate urine. Both colts were urinating excessively and drinking a lot of water, more than 80 liters each day. Tests showed that their kidneys were not responding properly to a hormone called vasopressin, which normally helps the body retain water. One of the colts also had a normal increase in vasopressin levels when deprived of water, confirming the diagnosis. The treatment for this condition is not mentioned, but the diagnosis indicates a significant health issue for both colts.
Abstract
Nephrogenic diabetes insipidus was diagnosed in two full sibling Thoroughbred colts. Each colt had a history of excessive urination. Extreme polydipsia (greater than 80 L per day) was documented in both colts. Inability to concentrate urine in response to water deprivation, infusion of hypertonic saline, or exogenous vasopressin administration indicated insensitivity of the collecting duct epithelial cells to vasopressin. A diagnosis of nephrogenic diabetes insipidus was further supported by a normal increase in plasma vasopressin concentration after water deprivation in the one colt in which such testing was pursued.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/8501698/