Peer-reviewed veterinary case report
Electrical stimulation improves colon movement in dogs with slow
By Sanmiguel, C P et al.·Published in Neurogastroenterology and motility·2006·Department of Gastroenterology, United States·View original on PubMed →
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Original publication title: Neural gastrointestinal electrical stimulation enhances colonic motility in a chronic canine model of delayed colonic transit.
- Species:
- dog
Plain-English summary
A group of nine mongrel dogs with delayed colonic transit (slow movement of food through the colon) was treated with neural gastrointestinal electrical stimulation (NGES) to see if it could help speed up their digestion. The dogs had electrodes implanted in their colons, and the treatment significantly reduced the time it took for them to evacuate their bowels from four days to just two days. The stimulation caused strong contractions in the colon, which were less effective when a certain medication (atropine) was given. Overall, NGES proved to be an effective way to enhance colonic movement in these dogs.
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Abstract
Neural gastrointestinal electrical stimulation (NGES) induces sequential contractions and enhances emptying in acute canine gastric and colonic models. This study was set to determine (i) the effect of NGES in a chronic canine model of delayed colonic transit and (ii) possible mechanism of action. Four pairs of electrodes were implanted in the distal colon of nine mongrel dogs. Delayed colonic transit was induced by diphenoxylate/atropine and alosetron. Transit was fluoroscopically determined by the rate of evacuation of radiopaque markers, and was tested twice in each dog, in random order, on and off stimulation. Two stimulation sequences, separated by 1 min, were delivered twice a day via exteriorized electrodes. Colonic manometry during stimulation was performed before and after intravenous (i.v.) injection of 1 mg of atropine. Complete evacuation of all markers was significantly shortened by NGES, from 4 days to 2 days, interquartile range 3-4 days vs 2-3 days, respectively, P = 0.016. NGES induced strong sequential contractions that were significantly diminished by atropine: 190.0 +/- 14.0 mmHg vs 48.7 +/- 19.4 mmHg, respectively (P < 0.001). NGES induces strong sequential colonic contractions and significantly accelerates movement of content in a canine model of delayed colonic transit. The effect is atropine sensitive.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16918729/