Peer-reviewed veterinary case report
Jack Russell terrier pup with worsening unsteady walk from brain
By Sacre, B J et al.·Published in The Cornell veterinarian·1993·Department of Pathology, United States·View original on PubMed →
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Original publication title: Neuroaxonal dystrophy in a Jack Russell terrier pup resembling human infantile neuroaxonal dystrophy.
- Species:
- dog
Plain-English summary
A 9-week-old Jack Russell terrier puppy was brought in for trouble with coordination and balance, known as ataxia. The vet found serious brain abnormalities, including missing parts of the brain and swelling, which are similar to a rare human condition called infantile neuroaxonal dystrophy. Unfortunately, due to the severity of the puppy's condition, treatment options were limited, and the prognosis was poor. This case highlights the importance of recognizing neurological symptoms in young dogs.
People also search for: Jack Russell puppy ataxia · dog brain problems · neuroaxonal dystrophy in dogs
Abstract
A 9-week-old Jack Russell terrier with progressive ataxia had histopathological lesions consistent with neuroaxonal dystrophy. Gross observation revealed absence of the septum pellucidum, hypoplasia of the corpus callosum and marked bilateral hydrocephalus. Light microscopy of the CNS revealed extensive axonal swellings principally in the gray matter of the brain stem where the sensory nuclei were most affected. Ultrastructurally, spheroids were identified as axonal terminals and probably dystrophic boutons; they were characterized by accumulations of membrane bound bodies. Clinical and morphological findings are similar to those identified in human infantile neuroaxonal dystrophy (Seitelberger's disease).
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8467699/