Peer-reviewed veterinary case report
Neurodegenerative Changes in Rat Brain in Streptozotocin Model of Alzheimer's Disease.
- Journal:
- Bulletin of experimental biology and medicine
- Year:
- 2019
- Authors:
- Voronkov, D N et al.
- Affiliation:
- Research Center of Neurology
- Species:
- rodent
Abstract
One of the most common models of sporadic form of Alzheimer's disease is injection of streptozotocin into the lateral ventricles of rat brain. In 3 months after this injection, an increase in the expression of astroglia in the corpus callosum and a decrease in the thickness of the corpus callosum and intensity of its staining with luxol fast blue were observed. This can reflect a decrease in the content of myelinated fibers. In layer V of the sensorimotor cortex, intensive degeneration of neurons was revealed. The lateral ventricles were significantly enlarged and the expression of PSA-NCAM protein, a marker of immature neurons, was reduced in subventricular zone, which can be associated with disturbed neurogenesi.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31028587/