Peer-reviewed veterinary case report
Neuroendocrine carcinoma of the apocrine glands of the anal sac in a dog.
- Journal:
- Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
- Year:
- 2011
- Authors:
- Ogawa, Bunichiro et al.
- Affiliation:
- Tokyo University of Agriculture and Technology · Japan
- Species:
- dog
Abstract
A perianal subcutaneous tumor involving the anal sac developed in an 8-year-old male mixed Labrador Retriever dog. Histologically, this tumor showed typical features of the solid-type carcinoma of the apocrine glands of the anal sac. However, neoplastic cells were immunoreactive for cytokeratin 8, chromogranin A, vasoactive intestinal peptide, neuron-specific enolase, and synaptophysin, and negative for S-100 protein, α-smooth muscle actin, vimentin, glucagon, insulin, somatostatin, carcinoembryonic antigen, serotonin, and parathyroid hormone-related protein. Considering the distribution of chromogranin A-positive cells within the anal sac apocrine glands, this tumor was diagnosed as neuroendocrine carcinoma originating from the apocrine glands of the anal sac.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21908338/