Peer-reviewed veterinary case report
Neurogenesis and major depression: implications from proteomic analyses of hippocampal proteins in a rat depression model.
- Journal:
- Neuroscience letters
- Year:
- 2007
- Authors:
- Mu, Jun et al.
- Affiliation:
- Department of Neurology · China
- Species:
- rodent
Abstract
Major depression is one of the most disabling disorders. Yet, the pathogenesis of this mental disorder is poorly understood. Hippocampus is generally believed to be associated with pathogenesis of depression. In this study, we adopted a proteomic approach to examine possible alterations of protein expression in the hippocampus of a rat depression model. Our results suggest that neurogenesis in hippocampus may play an important role in the pathogenesis of major depression.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17368938/