Peer-reviewed veterinary case report
Effects of enalapril and quinapril on heart hormones in Cavalier King
By Moesgaard, Sophia Gry et al.·Published in Journal of veterinary internal medicine·2005·Department of Basic Animal and Veterinary Sciences·View original on PubMed →
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Original publication title: Neurohormonal and circulatory effects of short-term treatment with enalapril and quinapril in dogs with asymptomatic mitral regurgitation.
- Species:
- dog
Plain-English summary
A group of Cavalier King Charles Spaniels with mild to severe mitral regurgitation (a heart valve issue) were treated with two different medications, quinapril and enalapril, to see how they affected heart function. Both medications helped lower certain harmful substances in the blood and improved heart measurements, but quinapril showed a bit more effectiveness in reducing the severity of the condition. The dogs were monitored over three weeks with blood tests and heart scans. Overall, both treatments were beneficial, but quinapril appeared to have a slight edge in improving heart health.
People also search for: Cavalier King Charles Spaniel heart problems · mitral regurgitation treatment for dogs · ACE inhibitors for dogs
Abstract
The aim of the study was to compare the effect of 2 angiotensin-converting enzyme (ACE) inhibitors on neurohormonal and circulatory variables in Cavalier King Charles Spaniels (CKCSs) with asymptomatic mitral regurgitation (MR). Ten CKCSs with mild to severe untreated MR were treated with 2 ACE inhibitors, quinapril and enalapril (each at 0.5 mg/kg PO q24h for 7 days), in a double-blind, crossover study with a washout period of 7 days between treatments. Blood samples were drawn and echocardiography was performed on days 0, 7, 14, and 21. Both treatments reduced ACE activity (P < .001) and increased renin activity (P < .001) and atrial natriuretic peptide concentration (P < .005). The ACE inhibitors had no effect on the concentrations of nitrate and nitrite (NOx) or asymmetric dimethylarginine (ADMA). On day 0, a lower NOx concentration (P = .02) was found in samples taken in the clinic as compared to samples taken in the homes of the dogs. Quinapril caused a significant reduction in more variables that reflect the severity of MR (eg, jet size and left ventricular end diastolic diameter) than did enalapril. However, in terms of specific variables, no significant difference was identified between the effects of the 2 treatments on MR. These results suggest that ACE inhibitors do not affect NOx and ADMA concentrations in asymptomatic dogs, but exercise, stress, or some combination may influence NOx concentrations in these dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16231716/