Peer-reviewed veterinary case report
Blindness seizures and brain disease in a cat with neuronal
By Bildfell, R et al.·Published in Veterinary pathology·1995·Department of Pathology and Microbiology, Canada·View original on PubMed →
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Original publication title: Neuronal ceroid-lipofuscinosis in a cat.
- Species:
- cat
Plain-English summary
A young adult domestic short-haired cat was euthanized due to severe neurological problems, including blindness, seizures, and confusion. Tests revealed a condition called neuronal ceroid-lipofuscinosis, which involves the buildup of certain pigments in the brain and nervous system. Unfortunately, this condition is progressive and led to the cat's decline. There are no effective treatments for this disease, and it primarily affects the nervous system.
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Abstract
Neuronal ceroid-lipofuscinosis was diagnosed in a young adult domestic short-haired cat euthanatized because of severe progressive neurologic disease. Clinical signs included blindness, seizures, and decreased mentation. An autofluorescent pigment, identified as ceroid-lipofuscin by electron microscopy and staining properties, was found within neurons of the central and peripheral nervous systems. A diffuse reactive astrocytosis accompanied by multifocal microgliosis was visible in all areas of the brain. Retinal atrophy with intraneuronal lipopigment accumulation was also identified. Contrary to the human neuronal ceroid-lipofuscinoses, pigment deposition appeared to be restricted to neural tissues.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8578638/