Peer-reviewed veterinary case report
Cat with seizures and vision loss diagnosed with neuronal
By Weissenböck, H & Rössel, C·Published in Journal of comparative pathology·1997·Institute of Pathology and Forensic Veterinary Medicine·View original on PubMed →
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Original publication title: Neuronal ceroid-lipofuscinosis in a domestic cat: clinical, morphological and immunohistochemical findings.
- Species:
- cat
Plain-English summary
A 9-month-old domestic shorthair cat was put to sleep due to serious health issues, including uncoordinated walking, muscle twitching (myoclonus), seizures, and poor vision. Tests showed that the cat had a rare condition called neuronal ceroid-lipofuscinosis (NCL), a type of neuronal storage disease where harmful substances build up in the brain. Unfortunately, there was no treatment available to reverse the condition, and the cat's symptoms indicated a severe decline in health.
People also search for: cat seizures · cat uncoordinated walking · cat vision problems · neuronal ceroid-lipofuscinosis in cats · cat myoclonus treatment
Abstract
A 9-month-old domestic shorthair cat was humanely killed because of uncoordinated gait, myoclonus, seizures and reduced vision. Histological, immunohistochemical and ultrastructural examination revealed a neuronal storage disease consistent with neuronal ceroid-lipofuscinosis (NCL). Neurons contained Sudan black- and luxol fast blue-positive material which was autofluorescent. Immunohistochemically, the storage material was found to contain subunit c of mitochondrial ATP synthase, a protein recently recognized as the main component of the storage material in NCL. Ultrastructurally, the material consisted of curvilinear and fingerprint bodies, which are indicative of NCL.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/9263841/