Peer-reviewed veterinary case report
Cat with gait problems and tremors diagnosed with neuronal
By Kuwamura, Mitsuru et al.·Published in The Journal of veterinary medical science·2009·Osaka Prefecture University, Japan·View original on PubMed →
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Original publication title: Neuronal ceroid-lipofuscinosis in a Japanese domestic shorthair cat.
- Species:
- cat
Plain-English summary
A 16-month-old female Japanese domestic shorthair cat showed signs of abnormal walking at just 5 months old, along with head shaking and tremors starting at 6 months. Blood tests revealed liver issues, indicated by high levels of certain enzymes. Unfortunately, the cat passed away, and a detailed examination of her brain showed unusual deposits in her neurons, similar to a condition seen in humans. This case adds to the rare instances of a genetic disorder known as ceroid-lipofuscinosis, which affects both the brain and liver.
People also search for: cat tremors and shaking · Japanese domestic shorthair cat liver disease · feline ceroid-lipofuscinosis symptoms
Abstract
A female Japanese domestic shorthair cat showed gait abnormality at 5 months of age, and head shaking and tremor became apparent from 6 months of age. Serum biochemistry at 13 months of age revealed markedly elevated ALT and ALP. The cat died at 16 months of age. Histopathologic examination revealed prominent cytoplasmic swelling of neurons with accumulation of yellowish pigments. The storage pigments stained positively with periodic acid Schiff reaction, Schmorl method, and Oil red O stain. Ultrastructurally, the neuronal storage consisted of aggregates of dense materials, similar to the granular osmiophilic deposits in infantile ceroid-lipofuscinosis in humans. Hepatocytes were markedly swollen and contained faintly eosinophilic inclusion. To our knowledge this case is the sixth case of feline ceroid-lipofuscinosis, which is characterized by granular osmiophilic dense bodies in the neurons and prominent involvement of hepatocytes.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19498297/