Peer-reviewed veterinary case report
Neurons contribute to pathology in a mouse model of Krabbe disease in a cell-autonomous manner.
- Journal:
- PLoS biology
- Year:
- 2022
- Authors:
- Brites, Pedro & Sousa, Monica M
- Affiliation:
- University of Porto
Abstract
In this issue of PLOS Biology, Kreher and colleagues show in a mouse model that in vivo, neurons and not only myelinating glia are primary effectors of disease progression in Krabbe disease. The neuron-specific model generated allows the unprecedented capacity to investigate the neuronal autonomous component of this disorder.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/35793314/